Insulin resistance is when cells stop responding to insulin’s signal to uptake glucose. It’s a hallmark of prediabetes, Type 2 diabetes, and other forms of metabolic dysfunction, and it manifests as several chronic disease, ranging from Alzheimer’s to polycystic ovarian syndrome. Dr. Rob Lustig and Dr. Dominic D’Agostino discuss the importance of monitoring insulin levels, why a high or increasing insulin level is a problem, and how insulin resistance hinders weight management.
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🎙 What Rob Lustig, MD, & Dr. Dominic D’Agostino, PhD, discuss:
(03:57) — What is insulin?
(06:55) — What is insulin resistance?
(18:00) — There are three types of insulin resistance
(38:00) — Weight management is not about calories in and calories out
(45:53) — Adding more insulin to the equation of Type 2 diabetes isn’t necessarily the answer
(51:20) — Insulin is a crucial biomarker to measure for metabolic health
(53:58) — Insulin resistance is a hinderance to weight management
(57:07) — The intake of too much leucine can lead to insulin resistance
(1:02:04) — Fiber feeds the gut microbiome and is crucial for metabolic health
(1:13:11) — Is intermittent fasting necessary?
Transcripts & Show notes
🔗 Helpful links:
Watch the conversation: https://youtu.be/dFOaBrujDHo
#255 - Why you might be a lean mass hyper-responder if you go keto but have high cholesterol | Dave Feldman, Dr. Nick Norwitz & Dr. Dominic D’Agostino
#254 - The writing of ‘Good Energy,’ your guide to taking charge of your metabolic health | Dr. Casey Means & Mike Haney
#252 - Why nutrition matters for brain health and how to modify your diet | Dr. Georgia Ede & Dr. Dominic D’Agostino - (Replay)
#251 - How to track your macros for fat loss and muscle gain | Josh Clemente & Dominic D'Agostino
#250 - Is fructose a driver of Alzheimer’s disease? | Dr. Richard Johnson & Dr. Rob Lustig - (Replay)
#249 - The links between gastrointestinal health, metabolic health, and fertility | Dr. Robin Rose & Ben Grynol - (Replay)
#248 - A low-carb diet may boost exercise performance and health | Professor Tim Noakes & Josh Clemente - (Replay)
#247 - Why sleep is one of the key aspects of your metabolic health | Mike Haney & Ben Grynol - (Replay)
#246 - How to keep your blood sugar more stable and why it matters for weight loss and overall health – Tips from Glucose Goddess | Jessie Inchauspé & Dr. Casey Means
#245 - Autoimmune disease, multiple sclerosis, holistic protocols, & metabolic health | Dr. Terry Wahls & Dr. Casey Means - (Replay)
#243 - Why sugary drinks can cause weight gain and low energy | Dr. Richard Johnson & Dr. Dominic D’Agostino
#244 - Where metabolic health and culture converge | Dhru Purohit & Austin McGuffie - (Replay)
#242 - Healthy eating for kids | Austin McGuffie & Ben Grynol - (Replay)
#241 - How environmental chemicals are making us sick and fat | Dr. Rob Lustig & Dr. Casey Means - (Replay)
#240 - Follow three diet rules to improve health, lose weight, and prevent diseases | Dr. Swaranjit Bhasin & Dr. Casey Means
#239 – Big Ag feeds into Big Pharma: Metabolic health benefits from regenerative farming | Dr. Robert Lustig & Ben Grynol - (Replay)
#238 - How regenerative farming boosts soil health and the nutrient content of the plants and animals we eat | Will Harris & Dr. Casey Means
#237 - Erectile dysfunction may mean chronic disease & early death | Dr. Merrill Matschke & Dr. Casey Means - (Replay)
#236 - How keto improves brain health and weight loss and combats chronic disease and disorders such as ADHD | Dr. Annette Bosworth & Dr. Casey Means
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