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About This Episode:
PREDIMED (Prevención con Dieta Mediterránea) is a landmark clinical trial conducted in Spain.
The study made a huge splash due to the rarity in nutrition of having large RCTs with hard endpoints. In addition, it had results of a large magnitude; showing a 30% reduction in cardiovascular events.
But the study did face criticisms and controversies over methodological issues, including randomization procedures at certain centers, ultimately leading to a retraction of the original paper and a re-analysis.
Participants in the PREDIMED trial were randomly assigned to one of three groups:
Despite the issues it still ends up being an incredibly useful source of data.
In this episode we discuss the findings from PREDIMED, some of the potential limitations, and where it sits among the wider Mediterranean Diet literature.
Note: This is a Premium-exclusive episode, so in order to listen to the full episode you’ll need to subscribe to Sigma Nutrition Premium.
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#292: Prof. Alexandra Johnstone, PhD – Appetite Control, Satiety & Diet Interventions
#291: Gab Fundaro, PhD – Gut Microbiome, Bacterial Diversity & the Impact of Diet & Probiotics
#290: Menno Henselmans & Eric Helms, PhD - Diet Breaks, Calorie Cycling & Muscle Retention
#289 Ciaran Fairman, PhD – Exercise Interventions in Cancer Treatment
#288: Ted Ryce: Meditation, Communication & Understanding Behaviours
#287: Gregg Slater - Dietary Fatigue, Nutrition Periodization & the Deficit-Adherence Model
#286: James Morton, PhD - Fuelling Elite Sport: Team Sky, Liverpool FC & Carbohydrate Periodization
#285: What is Health? A Conceptual Framework
#284: Simone Harding – Tackling Negative Body Image & Weight Stigma
#283: Alun Williams, PhD - The Genetics & Science Behind the Historic Caster Semenya/IAAF Case
#282: Louise Burke, PhD - Project Supernova: The Science of Fuelling Elite Athletes
#281: Jake Linardon, PhD – Eating Disorders, Binge Eating & Body Image
#280: Kirsty Elliot-Sale, PhD – Energy Availability, Menstrual Disorders & RED-S
#279: Avrum Bluming, MD & Carol Tavris, PhD – Estrogen, Menopause & Misconceptions About Hormone Replacement
#278: Jackson Peos, PhD – The ICECAP Trial, Intermittent Energy Restriction & the Science of Diet Breaks
#277: Eric Helms, PhD - Non-Quantitative Dieting, Personal Experiments & Optimal Weight Gain for Hypertrophy
#276: Nick Gant, PhD - Neurometabolism: Brain Function, Fatigue & Nutritient Interventions
#275: Kate Solovieva - Psychology, Empathy & Coping Strategies for Better Coaching
#274: James Lindsay, PhD - When Peer-Review Goes Wrong
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