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About This Episode:
PREDIMED (Prevención con Dieta Mediterránea) is a landmark clinical trial conducted in Spain.
The study made a huge splash due to the rarity in nutrition of having large RCTs with hard endpoints. In addition, it had results of a large magnitude; showing a 30% reduction in cardiovascular events.
But the study did face criticisms and controversies over methodological issues, including randomization procedures at certain centers, ultimately leading to a retraction of the original paper and a re-analysis.
Participants in the PREDIMED trial were randomly assigned to one of three groups:
Despite the issues it still ends up being an incredibly useful source of data.
In this episode we discuss the findings from PREDIMED, some of the potential limitations, and where it sits among the wider Mediterranean Diet literature.
Note: This is a Premium-exclusive episode, so in order to listen to the full episode you’ll need to subscribe to Sigma Nutrition Premium.
#353: James Hébert, ScD – Dietary Inflammatory Index
#352: Do Diets Even Work in the Long-term? - A Look at Weight Loss Maintenance
#351: Prof. Glenn Gibson - Human Gut Bacteriology, Prebiotics & Probiotics
#350: Peter Olusoga, PhD & Hugh Gilmore – Coaching Burnout: The Research & Applied Psychology
#349: Prof. Naomi Allen – How the UK Biobank is Powering Chronic Disease Research
#348: Omega-3 Supplementation & Heart Disease
#347: Alex Thomas - Advancing the Sports Nutritionist Profession
#346: Kathryn Bradbury, PhD – Diet & Colorectal Cancer Risk
#345: Rebecca Leech, PhD – Impact of Meal Patterning on Diet Quality & Health
#344: Prof. Martin Caraher – Food Poverty & Food Aid Provision
#343: Understanding Causality in Nutrition Science
#342: Are Vegan Diets Superior for Health?
#340: Ethics of Veganism & Omnivorism (Part 4) – Diana Rodgers, RD & Robb Wolf
#339: Prof. Corinna Hawkes - Food Policy, Food Systems & Public Health
#338: Ethics of Veganism & Omnivorism (Part 3) - Alex O' Connor
#337: Ethics of Veganism & Omnivorism (Part 2) – Prof. Paul Thompson
#336: Ethics of Veganism & Omnivorism (Part 1) – Andrew Chignell, PhD
#335: Kyra Bobinet, MD – Systems, Dietary Behaviour Change & the Iterative Mindset
#334: Austin Baraki, MD – Potential Harms of Screening, Overdiagnosis and Overtreatment
#333: Diet & Immunity
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