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About This Episode:
PREDIMED (Prevención con Dieta Mediterránea) is a landmark clinical trial conducted in Spain.
The study made a huge splash due to the rarity in nutrition of having large RCTs with hard endpoints. In addition, it had results of a large magnitude; showing a 30% reduction in cardiovascular events.
But the study did face criticisms and controversies over methodological issues, including randomization procedures at certain centers, ultimately leading to a retraction of the original paper and a re-analysis.
Participants in the PREDIMED trial were randomly assigned to one of three groups:
Despite the issues it still ends up being an incredibly useful source of data.
In this episode we discuss the findings from PREDIMED, some of the potential limitations, and where it sits among the wider Mediterranean Diet literature.
Note: This is a Premium-exclusive episode, so in order to listen to the full episode you’ll need to subscribe to Sigma Nutrition Premium.
#370: Jake Mey, PhD, RD - Dietetics, Evidence-based Practice & Translating Science into Advice
#369: Prof. Jason Gill - Population Cardiometabolic Disease Risk: Impact of Strength, Fitness & Activity
#368: Shannon Beer – Intentional Eating, Flourishing Health & Behavioural Psychology
#367: Gabrielle Fundaro, PhD – Mindful Eating, Facilitating Health Behaviour Change & Client-centred Coaching
#366: Listener Q&A
#365: David Robert Grimes, PhD – Conspiracy Theories & Bad Information: Why Are We Susceptible?
#364: Jake Linardon, PhD - Disordered Eating: Impact of Macro Tracking & Social Media
#363: Public Health Policy vs. Personal Responsibility: Evidence vs. Ideology
#362: Alistair Monteyne – Impact of Mycoprotein & Vegan Diets on Muscle Protein Synthesis
#361: Sarah Berry, PhD – The PREDICT Study, Postprandial Metabolism & Personalised Nutrition
#360: Nick Hiebert – Micronutrients, Anti-nutrients and Non-essential Nutrients
#359: Calorie Confusion - (Mis)Understanding Energy Balance
#358: Coffee & Health
#357: Nicky Keay, MB BChir – Female Athletes: Hormones, Energy Availability & the Menstrual Cycle
#356: Hana Kahleova, MD, PhD – Plant-based Diets, Meal Timing & Meal Frequency
#355: Is Time-restricted Eating Dead?: A Closer Look
#354: Problems with the Meta-Analysis in Nutrition
#353: James Hébert, ScD – Dietary Inflammatory Index
#352: Do Diets Even Work in the Long-term? - A Look at Weight Loss Maintenance
#351: Prof. Glenn Gibson - Human Gut Bacteriology, Prebiotics & Probiotics
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