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About This Episode:
PREDIMED (Prevención con Dieta Mediterránea) is a landmark clinical trial conducted in Spain.
The study made a huge splash due to the rarity in nutrition of having large RCTs with hard endpoints. In addition, it had results of a large magnitude; showing a 30% reduction in cardiovascular events.
But the study did face criticisms and controversies over methodological issues, including randomization procedures at certain centers, ultimately leading to a retraction of the original paper and a re-analysis.
Participants in the PREDIMED trial were randomly assigned to one of three groups:
Despite the issues it still ends up being an incredibly useful source of data.
In this episode we discuss the findings from PREDIMED, some of the potential limitations, and where it sits among the wider Mediterranean Diet literature.
Note: This is a Premium-exclusive episode, so in order to listen to the full episode you’ll need to subscribe to Sigma Nutrition Premium.
#333: Diet & Immunity
#332: Prof. Sam McConkey – COVID-19: Public Health Response, Clinical Presentation & Socioeconomics
#331: Prof. Roy Taylor – Diabetes Remission, Very-low Calorie Diets & the Twin Cycle Hypothesis
#330: Eric Trexler, PhD – Antioxidants, Oxidative Stress & Exercise Adaptations
#329: Diet & Inflammation
#328: Meeta Singh, MD – Sleep, Immunity & Mental Health
#327: David Dunne – Behavioural Science in Nutrition
#326: Krista Scott-Dixon, PhD – Adaptability & Autonomy in the Nutrition Coaching Process
#325: Kirk Parsley, MD - Stress, Sleep & Anxiety During a Pandemic
#324: Fatima Cody Stanford, MD – Obesity Treatment & Weight Bias
#323: COVID-19 & SARS-CoV-2 with Rizwan Sohail, MD
#322: Dominic Munnelly – Coaching People To Health: Philosophy, Empathy & Community
#321: Dave Feldman & Alan Flanagan – Debating LDL Causality & the “Lipid Triad”
#320: Hannah Ritchie, PhD – Environmental Impacts of our Diet: Climate, Carbon Footprint & Land Use
#319: Women in Science: Past Guests as Role Models in Nutrition
#318: Chris Melby, PhD – Impact of Energy Flux on Weight Loss Maintenance
#317: Understanding Diet & Heart Disease Risk
#316: Michael Grandner, PhD – Societal, Social & Psychological Influences on Sleep
#315: Samia Mora, MD – Lipids, Lipoproteins & Atherosclerosis
#314: Q&A – Hemochromatosis, Sodium, Bone Health, & More!
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