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About This Episode:
It has been clearly demonstrated that elevated LDL-cholesterol (LDL-C), or perhaps more specifically pro-atherogenic lipoproteins, is causal in atherosclerosis development in humans.
One crucial concept within this is that the risk relates not only to the magnitude of elevated LDL-C, but the duration of exposure. Thus, the role of LDL-C in driving atherosclerosis is referred to as a “cumulative, integrated exposure over the lifecourse”.
But, what exactly does this mean?
In this episode, Danny discusses the cumulative exposure model of LDL-C in atherosclerosis, the evidence supporting it, and the implications of this for the “debates” that get raised in relation to LDL-C (or apoB-containing lipoproteins) and heart disease.
Links:
#354: Problems with the Meta-Analysis in Nutrition
#353: James Hébert, ScD – Dietary Inflammatory Index
#352: Do Diets Even Work in the Long-term? - A Look at Weight Loss Maintenance
#351: Prof. Glenn Gibson - Human Gut Bacteriology, Prebiotics & Probiotics
#350: Peter Olusoga, PhD & Hugh Gilmore – Coaching Burnout: The Research & Applied Psychology
#349: Prof. Naomi Allen – How the UK Biobank is Powering Chronic Disease Research
#348: Omega-3 Supplementation & Heart Disease
#347: Alex Thomas - Advancing the Sports Nutritionist Profession
#346: Kathryn Bradbury, PhD – Diet & Colorectal Cancer Risk
#345: Rebecca Leech, PhD – Impact of Meal Patterning on Diet Quality & Health
#344: Prof. Martin Caraher – Food Poverty & Food Aid Provision
#343: Understanding Causality in Nutrition Science
#342: Are Vegan Diets Superior for Health?
#340: Ethics of Veganism & Omnivorism (Part 4) – Diana Rodgers, RD & Robb Wolf
#339: Prof. Corinna Hawkes - Food Policy, Food Systems & Public Health
#338: Ethics of Veganism & Omnivorism (Part 3) - Alex O' Connor
#337: Ethics of Veganism & Omnivorism (Part 2) – Prof. Paul Thompson
#336: Ethics of Veganism & Omnivorism (Part 1) – Andrew Chignell, PhD
#335: Kyra Bobinet, MD – Systems, Dietary Behaviour Change & the Iterative Mindset
#334: Austin Baraki, MD – Potential Harms of Screening, Overdiagnosis and Overtreatment
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