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About This Episode:
It has been clearly demonstrated that elevated LDL-cholesterol (LDL-C), or perhaps more specifically pro-atherogenic lipoproteins, is causal in atherosclerosis development in humans.
One crucial concept within this is that the risk relates not only to the magnitude of elevated LDL-C, but the duration of exposure. Thus, the role of LDL-C in driving atherosclerosis is referred to as a “cumulative, integrated exposure over the lifecourse”.
But, what exactly does this mean?
In this episode, Danny discusses the cumulative exposure model of LDL-C in atherosclerosis, the evidence supporting it, and the implications of this for the “debates” that get raised in relation to LDL-C (or apoB-containing lipoproteins) and heart disease.
Links:
#410: Q&A: Sodium, Protein, Quackery Tactics & More!
#409: Simon Hill – Shifting Towards a Healthier Diet
#408: Mario Kratz, PhD – Is Eating Full-fat Dairy, Low-fat Dairy, or No Dairy Better for Cardiometabolic Health?
#407: Polyphenols - Impact on Blood Pressure, Endothelial Function & Heart Disease Risk
#406: Polyphenols & Cognitive Health
#405: Adrian Brown, PhD - Dietary Strategies in Type 2 Diabetes
#404: Prof. Marion Hetherington – Psychology and Development of Food Preference & Eating Behaviour
#403 Prof. David Jacobs – Food Synergy & The Top-Down Approach to Nutrition Research
#402: Prof. Leanne Redman – Pregnancy, Maternal Diet & Intergenerational Transmission of Obesity
#401: Quack Asylum – Part 2: Greger, Berg & Saladino
#400: Quack Asylum – Part 1: Malhotra & DiNicolantonio
#399: Prof. James Betts – Does Fasting Have Benefits Beyond Those Caused By Calorie Restriction?
#398: Carole Hooven, PhD – Testosterone: Behavioural Endocrinology & Sex Differences
#397: Dietary Nitrates & Nitrites
#396: Leigh Frame, PhD – Nutrient Trials: RCT Design, Ethics and Placebo Groups
#395: Prof. Carel le Roux – Current Thinking in Obesity Treatment
#394: Gar Benn – Nutrition Coaching Q&A
#393: Vitamin D: Does Supplementation Actually Improve Health?
#392: Clare Pettinger, PhD, RD – Environmentally Sustainable Diets & Food Access
#391: Is There a Body Weight Set Point?: Models of Body Mass Regulation
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