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About This Episode:
It has been clearly demonstrated that elevated LDL-cholesterol (LDL-C), or perhaps more specifically pro-atherogenic lipoproteins, is causal in atherosclerosis development in humans.
One crucial concept within this is that the risk relates not only to the magnitude of elevated LDL-C, but the duration of exposure. Thus, the role of LDL-C in driving atherosclerosis is referred to as a “cumulative, integrated exposure over the lifecourse”.
But, what exactly does this mean?
In this episode, Danny discusses the cumulative exposure model of LDL-C in atherosclerosis, the evidence supporting it, and the implications of this for the “debates” that get raised in relation to LDL-C (or apoB-containing lipoproteins) and heart disease.
Links:
#333: Diet & Immunity
#332: Prof. Sam McConkey – COVID-19: Public Health Response, Clinical Presentation & Socioeconomics
#331: Prof. Roy Taylor – Diabetes Remission, Very-low Calorie Diets & the Twin Cycle Hypothesis
#330: Eric Trexler, PhD – Antioxidants, Oxidative Stress & Exercise Adaptations
#329: Diet & Inflammation
#328: Meeta Singh, MD – Sleep, Immunity & Mental Health
#327: David Dunne – Behavioural Science in Nutrition
#326: Krista Scott-Dixon, PhD – Adaptability & Autonomy in the Nutrition Coaching Process
#325: Kirk Parsley, MD - Stress, Sleep & Anxiety During a Pandemic
#324: Fatima Cody Stanford, MD – Obesity Treatment & Weight Bias
#323: COVID-19 & SARS-CoV-2 with Rizwan Sohail, MD
#322: Dominic Munnelly – Coaching People To Health: Philosophy, Empathy & Community
#321: Dave Feldman & Alan Flanagan – Debating LDL Causality & the “Lipid Triad”
#320: Hannah Ritchie, PhD – Environmental Impacts of our Diet: Climate, Carbon Footprint & Land Use
#319: Women in Science: Past Guests as Role Models in Nutrition
#318: Chris Melby, PhD – Impact of Energy Flux on Weight Loss Maintenance
#317: Understanding Diet & Heart Disease Risk
#316: Michael Grandner, PhD – Societal, Social & Psychological Influences on Sleep
#315: Samia Mora, MD – Lipids, Lipoproteins & Atherosclerosis
#314: Q&A – Hemochromatosis, Sodium, Bone Health, & More!
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