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About This Episode:
It has been clearly demonstrated that elevated LDL-cholesterol (LDL-C), or perhaps more specifically pro-atherogenic lipoproteins, is causal in atherosclerosis development in humans.
One crucial concept within this is that the risk relates not only to the magnitude of elevated LDL-C, but the duration of exposure. Thus, the role of LDL-C in driving atherosclerosis is referred to as a “cumulative, integrated exposure over the lifecourse”.
But, what exactly does this mean?
In this episode, Danny discusses the cumulative exposure model of LDL-C in atherosclerosis, the evidence supporting it, and the implications of this for the “debates” that get raised in relation to LDL-C (or apoB-containing lipoproteins) and heart disease.
Links:
#429: Kevin Hall, PhD & Stephan Guyenet, PhD - Carbohydrate-Insulin Model vs. Energy Balance Model
#428: Food Environments
Can You ‘Study’ Nutrition Science with a Podcast? Here’s How. (Including a Time-sensitive Announcement)
#427: Jacob Schepis – Evidence-Based Coaching: Desirable Goal or Unattainable Burden for Fitness Professionals?
#426: Jaebian Rosario – How Social Identity and Idealogical Extremes Impact Scientific Discussion
#425: Prof. Anna Krylov – When Ideology Hurts Scientific Discourse
#424: Is Low Cholesterol Bad For You?!
#423: Zoya Huschtscha, PhD – Understanding Sarcopenia & Potential Interventions
#422: Psychobiotics – Can Probiotics Improve Mood-related Disorders?
#421: Brendon Stubbs, PhD – The Research on Depression & Physical Activity
#420: Cannabis – Kevin Boehnke, PhD & Carrie Cuttler, PhD
#419: Nathan Bryan, PhD – Role of Nitric Oxide in Human Health
#418: Should We Consume a Direct Source of DHA?
#417: Austin Baraki, MD – What Do Nutrient Blood Tests Actually Tell Us?: Understanding Biomarkers
#416: David Nunan, PhD – Evidence-Informed Health Care: Evidence-based Medicine 2.0
#415: Prof. Bruce Neal – Can Salt Substitutes Reduce Cardiac Events & Death?
#414: Will Machine Learning Overtake Traditional Nutrition Research Methods?
#413: Anthony Fardet, PhD – Nutritional Reductionism, the Food Matrix & Impact of Processing
#412: Eirini Dimidi, PhD – Diet, Chronic Constipation and the Gut
#411: Bone Health & Nutrition
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