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About This Episode:
It has been clearly demonstrated that elevated LDL-cholesterol (LDL-C), or perhaps more specifically pro-atherogenic lipoproteins, is causal in atherosclerosis development in humans.
One crucial concept within this is that the risk relates not only to the magnitude of elevated LDL-C, but the duration of exposure. Thus, the role of LDL-C in driving atherosclerosis is referred to as a “cumulative, integrated exposure over the lifecourse”.
But, what exactly does this mean?
In this episode, Danny discusses the cumulative exposure model of LDL-C in atherosclerosis, the evidence supporting it, and the implications of this for the “debates” that get raised in relation to LDL-C (or apoB-containing lipoproteins) and heart disease.
Links:
#390: Gil Carvalho MD, PhD – Dairy, Olive Oil & Diet Debates: Understanding Evidence
#389: Renee McGregor, RD – Why Are Athletes Under-Eating?
#388: Consequences of Weight Stigma and Weight Bias
#387: Shift Work and Health
#386: Deirdre Tobias, ScD – Study Design, Diet Collection Methods and Nutrition Epidemiology
#385: Insulin Resistance & Diet
#384: Research Review: The Interference Effect & Concurrent Training
#383: Irritable Bowel Syndrome (IBS) & Diet
#382: Andy Morgan – Practicalities of Body Composition Change
#381: Prof. Chris Packard – LDL Cholesterol, ApoB & Atherosclerosis
#380: Prof. Barry Popkin – The Nutrition Transition & Using Policy Actions to Create Healthier Diets
#379: Obesity & Chronic Disease Risk with Dr. Spencer Nadolsky
#378: Nutritional Epidemiology
#377: Herman Pontzer, PhD – Metabolism, Mitochondria & Evolutionary Biology
#376: Kevin Hall, PhD – Plant-based Diet vs. Ketogenic Diet: Impact on Calorie Intake
#375: Salt, Sodium & Health
#374: How to Plan a Fighter’s Diet
#373: Alcohol & Health: Is Zero Better Than Some?
#372: Mike Israetel, PhD – Bodybuilding, Avoiding Suffering & Lessons for Life
#371: Dietary Cholesterol – Are Eggs & Cholesterol-rich Foods a Cause for Concern?
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