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About This Episode:
In 1959 a landmark clinical trial, often referred to as the LA Veterans Study, began with the aim to investigate the effects of replacing dietary saturated fats with polyunsaturated fats, on the progression of atherosclerosis and cardiovascular outcomes.
This was an eight-year clinical trial in 846 domiciled male veterans in the US. The diets between the control and experimental groups differed by saturated fat and polyunsaturated fat (particularly linoleic acid) content, but were similar in calories and total dietary fat.
The findings of the study suggested that replacing saturated fat with polyunsaturated fat was beneficial for reducing heart disease risk. However, the study also reported an unexpected increase in non-cardiac mortality in the intervention group, which raised concerns.
In this episode, we discuss why the LA Veterans Study was such a seminal trial and what we can learn from it.
SNP11: The Death of Domain Expertise
#460: Dr. Priya Sumithran – Body Fat Regulation, Pros & Cons of Weight Loss Interventions, and GLP-1 Receptor Agonists
#459: Nicky Keay, MB BChir – Hormones & Healthspan: The Endocrine System Across the Life Course
What Are Stable Isotopes? How Are Tracers Used in Nutrition Research? (Preview)
#458: How Foods Impact Satiety, Hunger & Appetite
#457: Austin Robinson, PhD – Salt Sensitive vs Salt Resistant, Impacts of Sodium on Health, & Racial Differences in Risk
#456: Prof. Glenn McConell – Glucose Uptake During Exercise & Muscle Insulin Sensitivity
#455: Jill Joyce, PhD – Improving the Diets of Tactical Populations
SNP9: AMA – Blood Pressure, LDL Lowering, PCOS & More!
#454: Eric Helms, PhD – Plant or Animal Protein: Rethinking Protein & Muscle
#453: Nick Gant, PhD – Cognitive Performance: Impact of Caffeine, Nicotine & Creatine (Rebroadcast)
#452: Stuart Phillips, PhD - Bacterially Synthesized Whey, Plant vs. Animal Proteins, Muscle & Extended Fasts, & Much More
#451: Potassium & Blood Pressure: Influence of Sex & Sodium
#450: Megan Rossi, PhD, RD – Diet For a Healthy Gut: Diversity, Fiber Types & Gut Health Pseudoscience
#449: Do Artificial Sweeteners Increase Cancer Risk? (Study Analysis)
#448: Prof. Norman Temple – Can Science Answer Diet-Health Questions?
#447: Does Eating Fish Increase Skin Cancer Risk? Study Analysis
SNP7: Stephan Guyenet, PhD - Ask Me Anything!
#446: How Climate Change Impacts Nutrient Status
#445: Dr. Hazel Wallace - Nutrition for Women’s Health
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