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About This Episode:
In 1959 a landmark clinical trial, often referred to as the LA Veterans Study, began with the aim to investigate the effects of replacing dietary saturated fats with polyunsaturated fats, on the progression of atherosclerosis and cardiovascular outcomes.
This was an eight-year clinical trial in 846 domiciled male veterans in the US. The diets between the control and experimental groups differed by saturated fat and polyunsaturated fat (particularly linoleic acid) content, but were similar in calories and total dietary fat.
The findings of the study suggested that replacing saturated fat with polyunsaturated fat was beneficial for reducing heart disease risk. However, the study also reported an unexpected increase in non-cardiac mortality in the intervention group, which raised concerns.
In this episode, we discuss why the LA Veterans Study was such a seminal trial and what we can learn from it.
#390: Gil Carvalho MD, PhD – Dairy, Olive Oil & Diet Debates: Understanding Evidence
#389: Renee McGregor, RD – Why Are Athletes Under-Eating?
#388: Consequences of Weight Stigma and Weight Bias
#387: Shift Work and Health
#386: Deirdre Tobias, ScD – Study Design, Diet Collection Methods and Nutrition Epidemiology
#385: Insulin Resistance & Diet
#384: Research Review: The Interference Effect & Concurrent Training
#383: Irritable Bowel Syndrome (IBS) & Diet
#382: Andy Morgan – Practicalities of Body Composition Change
#381: Prof. Chris Packard – LDL Cholesterol, ApoB & Atherosclerosis
#380: Prof. Barry Popkin – The Nutrition Transition & Using Policy Actions to Create Healthier Diets
#379: Obesity & Chronic Disease Risk with Dr. Spencer Nadolsky
#378: Nutritional Epidemiology
#377: Herman Pontzer, PhD – Metabolism, Mitochondria & Evolutionary Biology
#376: Kevin Hall, PhD – Plant-based Diet vs. Ketogenic Diet: Impact on Calorie Intake
#375: Salt, Sodium & Health
#374: How to Plan a Fighter’s Diet
#373: Alcohol & Health: Is Zero Better Than Some?
#372: Mike Israetel, PhD – Bodybuilding, Avoiding Suffering & Lessons for Life
#371: Dietary Cholesterol – Are Eggs & Cholesterol-rich Foods a Cause for Concern?
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