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About This Episode:
In 1959 a landmark clinical trial, often referred to as the LA Veterans Study, began with the aim to investigate the effects of replacing dietary saturated fats with polyunsaturated fats, on the progression of atherosclerosis and cardiovascular outcomes.
This was an eight-year clinical trial in 846 domiciled male veterans in the US. The diets between the control and experimental groups differed by saturated fat and polyunsaturated fat (particularly linoleic acid) content, but were similar in calories and total dietary fat.
The findings of the study suggested that replacing saturated fat with polyunsaturated fat was beneficial for reducing heart disease risk. However, the study also reported an unexpected increase in non-cardiac mortality in the intervention group, which raised concerns.
In this episode, we discuss why the LA Veterans Study was such a seminal trial and what we can learn from it.
#429: Kevin Hall, PhD & Stephan Guyenet, PhD - Carbohydrate-Insulin Model vs. Energy Balance Model
#428: Food Environments
Can You ‘Study’ Nutrition Science with a Podcast? Here’s How. (Including a Time-sensitive Announcement)
#427: Jacob Schepis – Evidence-Based Coaching: Desirable Goal or Unattainable Burden for Fitness Professionals?
#426: Jaebian Rosario – How Social Identity and Idealogical Extremes Impact Scientific Discussion
#425: Prof. Anna Krylov – When Ideology Hurts Scientific Discourse
#424: Is Low Cholesterol Bad For You?!
#423: Zoya Huschtscha, PhD – Understanding Sarcopenia & Potential Interventions
#422: Psychobiotics – Can Probiotics Improve Mood-related Disorders?
#421: Brendon Stubbs, PhD – The Research on Depression & Physical Activity
#420: Cannabis – Kevin Boehnke, PhD & Carrie Cuttler, PhD
#419: Nathan Bryan, PhD – Role of Nitric Oxide in Human Health
#418: Should We Consume a Direct Source of DHA?
#417: Austin Baraki, MD – What Do Nutrient Blood Tests Actually Tell Us?: Understanding Biomarkers
#416: David Nunan, PhD – Evidence-Informed Health Care: Evidence-based Medicine 2.0
#415: Prof. Bruce Neal – Can Salt Substitutes Reduce Cardiac Events & Death?
#414: Will Machine Learning Overtake Traditional Nutrition Research Methods?
#413: Anthony Fardet, PhD – Nutritional Reductionism, the Food Matrix & Impact of Processing
#412: Eirini Dimidi, PhD – Diet, Chronic Constipation and the Gut
#411: Bone Health & Nutrition
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