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About This Episode:
The Sydney Diet-Heart Study was a clinical trial conducted in the 1960s and 1970s that aimed to examine the hypothesis that reducing saturated fat intake in the diet would lead to a reduced risk of heart disease.
However, it really only gained attention after a more recent re-analysis by Ramsden et al., which in recent years has been used as supporting evidence for the idea that increased polyunsaturated fat (PUFA), and specifically linoleic acid, in addition to reduced saturated fat intake, can increase heart disease risk.
This was based on the findings that substituting linoleic acid in place of saturated fat increased all-cause, CVD and CHD mortality.
This is of course counter to prevailing consensus and guidelines in this area, which routinely show reduced risk on replacing SFA with PUFA.
Could this trial undermine the common conclusions that replacing saturated fat with polyunsaturated fat decreases heart disease risk?
In this episode Alan and Danny discuss some of the crucial aspects to understand about this study and what it means for what conclusions can be made about the impact of PUFA broadly, and linoleic acid specifically, on our health.
SNP11: The Death of Domain Expertise
#460: Dr. Priya Sumithran – Body Fat Regulation, Pros & Cons of Weight Loss Interventions, and GLP-1 Receptor Agonists
#459: Nicky Keay, MB BChir – Hormones & Healthspan: The Endocrine System Across the Life Course
What Are Stable Isotopes? How Are Tracers Used in Nutrition Research? (Preview)
#458: How Foods Impact Satiety, Hunger & Appetite
#457: Austin Robinson, PhD – Salt Sensitive vs Salt Resistant, Impacts of Sodium on Health, & Racial Differences in Risk
#456: Prof. Glenn McConell – Glucose Uptake During Exercise & Muscle Insulin Sensitivity
#455: Jill Joyce, PhD – Improving the Diets of Tactical Populations
SNP9: AMA – Blood Pressure, LDL Lowering, PCOS & More!
#454: Eric Helms, PhD – Plant or Animal Protein: Rethinking Protein & Muscle
#453: Nick Gant, PhD – Cognitive Performance: Impact of Caffeine, Nicotine & Creatine (Rebroadcast)
#452: Stuart Phillips, PhD - Bacterially Synthesized Whey, Plant vs. Animal Proteins, Muscle & Extended Fasts, & Much More
#451: Potassium & Blood Pressure: Influence of Sex & Sodium
#450: Megan Rossi, PhD, RD – Diet For a Healthy Gut: Diversity, Fiber Types & Gut Health Pseudoscience
#449: Do Artificial Sweeteners Increase Cancer Risk? (Study Analysis)
#448: Prof. Norman Temple – Can Science Answer Diet-Health Questions?
#447: Does Eating Fish Increase Skin Cancer Risk? Study Analysis
SNP7: Stephan Guyenet, PhD - Ask Me Anything!
#446: How Climate Change Impacts Nutrient Status
#445: Dr. Hazel Wallace - Nutrition for Women’s Health
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