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About This Episode:
The Sydney Diet-Heart Study was a clinical trial conducted in the 1960s and 1970s that aimed to examine the hypothesis that reducing saturated fat intake in the diet would lead to a reduced risk of heart disease.
However, it really only gained attention after a more recent re-analysis by Ramsden et al., which in recent years has been used as supporting evidence for the idea that increased polyunsaturated fat (PUFA), and specifically linoleic acid, in addition to reduced saturated fat intake, can increase heart disease risk.
This was based on the findings that substituting linoleic acid in place of saturated fat increased all-cause, CVD and CHD mortality.
This is of course counter to prevailing consensus and guidelines in this area, which routinely show reduced risk on replacing SFA with PUFA.
Could this trial undermine the common conclusions that replacing saturated fat with polyunsaturated fat decreases heart disease risk?
In this episode Alan and Danny discuss some of the crucial aspects to understand about this study and what it means for what conclusions can be made about the impact of PUFA broadly, and linoleic acid specifically, on our health.
#492: How Does Weight Cycling Impact Long-term Health?
#491: Do High Protein Intakes Cause Insulin Resistance?
#490: How Does Exercise Impact Beta-cell Function in Type 2 Diabetes? – Mark Lyngbæk, MD
What is a Causal Risk Factor? (AMA with Alan)
#489: Inequalities in Diabetes Outcomes for African & Caribbean Communities – Prof. Louise Goff
#488: Does Time of Day Impact Hunger, Appetite & Satiety?
#487: Weight Cutting in Combat Sports – Jordan Sullivan
#486: Blood Glucose Spikes: How High is Too High? – Mario Kratz, PhD & Nicola Guess, PhD
#485: Does Menopause Alter Appetite?
SNP18: What is a Healthy Low-Carb Diet?
#484: Is Metabolic Adaptation an Illusion? – Eric Trexler, PhD
#483: What are the Effects of Very High Fiber Intakes?
#482: Carbohydrate Quality & Health – Andrew Reynolds, PhD
Is Personalized Nutrition Superior to General Nutrition Advice? (SNP 17)
#481: Why Saturated Fat Really Does Impact Heart Disease Risk
#480: How Much Fiber Do We Need for Good Health? – Prof. Joanne Slavin
#479: Blood Glucose, CGM Use, Diabetes Remission & High-Protein for Diabetes – Nicola Guess, PhD, RD
#478: Exposures in Nutrition – Why They’re Crucial to Understand
SNP16: A Dairy Fat Paradox? – Saturated Fat, Food Matrices & Heart Disease
#477: Effect of Different Diets on Cholesterol, Lipoproteins and Discordance – Ian Davies, PhD
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