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About This Episode:
The Sydney Diet-Heart Study was a clinical trial conducted in the 1960s and 1970s that aimed to examine the hypothesis that reducing saturated fat intake in the diet would lead to a reduced risk of heart disease.
However, it really only gained attention after a more recent re-analysis by Ramsden et al., which in recent years has been used as supporting evidence for the idea that increased polyunsaturated fat (PUFA), and specifically linoleic acid, in addition to reduced saturated fat intake, can increase heart disease risk.
This was based on the findings that substituting linoleic acid in place of saturated fat increased all-cause, CVD and CHD mortality.
This is of course counter to prevailing consensus and guidelines in this area, which routinely show reduced risk on replacing SFA with PUFA.
Could this trial undermine the common conclusions that replacing saturated fat with polyunsaturated fat decreases heart disease risk?
In this episode Alan and Danny discuss some of the crucial aspects to understand about this study and what it means for what conclusions can be made about the impact of PUFA broadly, and linoleic acid specifically, on our health.
#507: Does a Higher Portfolio Diet Score Reduce Heart Disease? – Andrea Glenn, PhD
Listener Q&A: Homocysteine, MUFA, Healhty BMI, and more! (Preview)
#506 Sports Nutrition: Translating Research to Practice – Andreas Kasper, PhD
#505: Oslo Diet-Heart Study: Cholesterol-lowering Diets & Cardiovascular Events
#504: Vegetable Oil vs. Saturated Fat – Analysis of the LA Veterans Study
#503: Lyon Diet Heart Study – Canola Oil, “Mediterranean” Diets & Minimizing Bias
Addressing Some Criticisms of Nutritional Epidemiology (SNP 23)
#501: Sex-based Training Recommendations: Evidence-based or Hype? – David Nolan, PhD
#500 – The Big Unanswered Questions in Nutrition Science
#499: How Sensory Cues Impact Food Choice & Behavior – Prof. Ciarán Forde
The PREDIMED Trial – Controversy, Criticisms, & Lessons Learned (SNP 22)
#498: The PROPEL Trial & Weight Loss Interventions in Primary Care – John Apolzan, PhD
#497: Are Food Frequency Questionnaires Reliable?
SNP21: Sick Individuals and Sick Populations
#496: ATBC Cancer Prevention Study – Crucial Lessons
#495: Circadian Clocks in Muscle & Exercise as a Time Cue – Prof. Karyn Esser
#494: Multiple Risk Factor Intervention Trial
#493: The Keys Equation – How Dietary Fats Impact Blood Cholesterol
SNP20: The Cumulative Exposure Model of LDL-C & Heart Disease
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