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About This Episode:
The Sydney Diet-Heart Study was a clinical trial conducted in the 1960s and 1970s that aimed to examine the hypothesis that reducing saturated fat intake in the diet would lead to a reduced risk of heart disease.
However, it really only gained attention after a more recent re-analysis by Ramsden et al., which in recent years has been used as supporting evidence for the idea that increased polyunsaturated fat (PUFA), and specifically linoleic acid, in addition to reduced saturated fat intake, can increase heart disease risk.
This was based on the findings that substituting linoleic acid in place of saturated fat increased all-cause, CVD and CHD mortality.
This is of course counter to prevailing consensus and guidelines in this area, which routinely show reduced risk on replacing SFA with PUFA.
Could this trial undermine the common conclusions that replacing saturated fat with polyunsaturated fat decreases heart disease risk?
In this episode Alan and Danny discuss some of the crucial aspects to understand about this study and what it means for what conclusions can be made about the impact of PUFA broadly, and linoleic acid specifically, on our health.
#476: Fructose in Perspective – Dietary Villain or Misunderstood Nutrient?
#475: Is Food Addiction Real? – Charlotte Hardman, PhD
SNP15: AMA – Semaglutide, “Carni-nutrients”, Sweating From Caffeine, & More
#474: Glucose Peaks & Variability – Is Lower Better?
#473: Diet & Depression (What Do We Actually Know?) – Nicole Lippman-Barile, PhD
#472: Compared To What? – Understanding Food Substitution Analysis & Adjustment Models
#471: Salt & Bone Health – Is There Cause For Concern?
SNP14: Nutrition Coaching Roundtable (Helms, Huschtscha & Baker)
#470: Melatonin, Meal Timing & Glucose Tolerance
#469: Chrononutrition – New Findings & Updated Views
#468: High Sugar Intakes Without Excess Calories: Harmful or Benign?
SNP13: Intuitive Eating Debate – with Jackson Peos, PhD
#467: Iron Issues in Athletes – Prof. Pete Peeling
#466: Iron Absorption from Foods & Supplements – Prof. Paul Sharp
#465: Diagnosing & Treating Iron Deficiency & Excess – Austin Baraki, MD
#464: Do Sugar Taxes Work?: Evidence on Potential Policies - Kathryn Backholer, PhD
SNP12: The Big Breakfast Study
#463: Do Vegan Diets Cause Depression?
#462: Gyorgy Scrinis, PhD – Ultra-Processed Foods, Nutritionism and Current Food Systems
#461: Prof. Emma Boyland – How Food Marketing Impacts Eating Behaviour
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