Links:
About This Episode:
PREDIMED (Prevención con Dieta Mediterránea) is a landmark clinical trial conducted in Spain.
The study made a huge splash due to the rarity in nutrition of having large RCTs with hard endpoints. In addition, it had results of a large magnitude; showing a 30% reduction in cardiovascular events.
But the study did face criticisms and controversies over methodological issues, including randomization procedures at certain centers, ultimately leading to a retraction of the original paper and a re-analysis.
Participants in the PREDIMED trial were randomly assigned to one of three groups:
Despite the issues it still ends up being an incredibly useful source of data.
In this episode we discuss the findings from PREDIMED, some of the potential limitations, and where it sits among the wider Mediterranean Diet literature.
Note: This is a Premium-exclusive episode, so in order to listen to the full episode you’ll need to subscribe to Sigma Nutrition Premium.
#410: Q&A: Sodium, Protein, Quackery Tactics & More!
#409: Simon Hill – Shifting Towards a Healthier Diet
#408: Mario Kratz, PhD – Is Eating Full-fat Dairy, Low-fat Dairy, or No Dairy Better for Cardiometabolic Health?
#407: Polyphenols - Impact on Blood Pressure, Endothelial Function & Heart Disease Risk
#406: Polyphenols & Cognitive Health
#405: Adrian Brown, PhD - Dietary Strategies in Type 2 Diabetes
#404: Prof. Marion Hetherington – Psychology and Development of Food Preference & Eating Behaviour
#403 Prof. David Jacobs – Food Synergy & The Top-Down Approach to Nutrition Research
#402: Prof. Leanne Redman – Pregnancy, Maternal Diet & Intergenerational Transmission of Obesity
#401: Quack Asylum – Part 2: Greger, Berg & Saladino
#400: Quack Asylum – Part 1: Malhotra & DiNicolantonio
#399: Prof. James Betts – Does Fasting Have Benefits Beyond Those Caused By Calorie Restriction?
#398: Carole Hooven, PhD – Testosterone: Behavioural Endocrinology & Sex Differences
#397: Dietary Nitrates & Nitrites
#396: Leigh Frame, PhD – Nutrient Trials: RCT Design, Ethics and Placebo Groups
#395: Prof. Carel le Roux – Current Thinking in Obesity Treatment
#394: Gar Benn – Nutrition Coaching Q&A
#393: Vitamin D: Does Supplementation Actually Improve Health?
#392: Clare Pettinger, PhD, RD – Environmentally Sustainable Diets & Food Access
#391: Is There a Body Weight Set Point?: Models of Body Mass Regulation
Create your
podcast in
minutes
It is Free
Good Mood Revolution
Practically Healthy by Dr. Melina
ZOE Science & Nutrition
Intermittent Fasting Stories
LONGEVITY with Nathalie Niddam
Nutrition Diva