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About This Episode:
PREDIMED (Prevención con Dieta Mediterránea) is a landmark clinical trial conducted in Spain.
The study made a huge splash due to the rarity in nutrition of having large RCTs with hard endpoints. In addition, it had results of a large magnitude; showing a 30% reduction in cardiovascular events.
But the study did face criticisms and controversies over methodological issues, including randomization procedures at certain centers, ultimately leading to a retraction of the original paper and a re-analysis.
Participants in the PREDIMED trial were randomly assigned to one of three groups:
Despite the issues it still ends up being an incredibly useful source of data.
In this episode we discuss the findings from PREDIMED, some of the potential limitations, and where it sits among the wider Mediterranean Diet literature.
Note: This is a Premium-exclusive episode, so in order to listen to the full episode you’ll need to subscribe to Sigma Nutrition Premium.
#429: Kevin Hall, PhD & Stephan Guyenet, PhD - Carbohydrate-Insulin Model vs. Energy Balance Model
#428: Food Environments
Can You ‘Study’ Nutrition Science with a Podcast? Here’s How. (Including a Time-sensitive Announcement)
#427: Jacob Schepis – Evidence-Based Coaching: Desirable Goal or Unattainable Burden for Fitness Professionals?
#426: Jaebian Rosario – How Social Identity and Idealogical Extremes Impact Scientific Discussion
#425: Prof. Anna Krylov – When Ideology Hurts Scientific Discourse
#424: Is Low Cholesterol Bad For You?!
#423: Zoya Huschtscha, PhD – Understanding Sarcopenia & Potential Interventions
#422: Psychobiotics – Can Probiotics Improve Mood-related Disorders?
#421: Brendon Stubbs, PhD – The Research on Depression & Physical Activity
#420: Cannabis – Kevin Boehnke, PhD & Carrie Cuttler, PhD
#419: Nathan Bryan, PhD – Role of Nitric Oxide in Human Health
#418: Should We Consume a Direct Source of DHA?
#417: Austin Baraki, MD – What Do Nutrient Blood Tests Actually Tell Us?: Understanding Biomarkers
#416: David Nunan, PhD – Evidence-Informed Health Care: Evidence-based Medicine 2.0
#415: Prof. Bruce Neal – Can Salt Substitutes Reduce Cardiac Events & Death?
#414: Will Machine Learning Overtake Traditional Nutrition Research Methods?
#413: Anthony Fardet, PhD – Nutritional Reductionism, the Food Matrix & Impact of Processing
#412: Eirini Dimidi, PhD – Diet, Chronic Constipation and the Gut
#411: Bone Health & Nutrition
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