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About This Episode:
In 1959 a landmark clinical trial, often referred to as the LA Veterans Study, began with the aim to investigate the effects of replacing dietary saturated fats with polyunsaturated fats, on the progression of atherosclerosis and cardiovascular outcomes.
This was an eight-year clinical trial in 846 domiciled male veterans in the US. The diets between the control and experimental groups differed by saturated fat and polyunsaturated fat (particularly linoleic acid) content, but were similar in calories and total dietary fat.
The findings of the study suggested that replacing saturated fat with polyunsaturated fat was beneficial for reducing heart disease risk. However, the study also reported an unexpected increase in non-cardiac mortality in the intervention group, which raised concerns.
In this episode, we discuss why the LA Veterans Study was such a seminal trial and what we can learn from it.
#354: Problems with the Meta-Analysis in Nutrition
#353: James Hébert, ScD – Dietary Inflammatory Index
#352: Do Diets Even Work in the Long-term? - A Look at Weight Loss Maintenance
#351: Prof. Glenn Gibson - Human Gut Bacteriology, Prebiotics & Probiotics
#350: Peter Olusoga, PhD & Hugh Gilmore – Coaching Burnout: The Research & Applied Psychology
#349: Prof. Naomi Allen – How the UK Biobank is Powering Chronic Disease Research
#348: Omega-3 Supplementation & Heart Disease
#347: Alex Thomas - Advancing the Sports Nutritionist Profession
#346: Kathryn Bradbury, PhD – Diet & Colorectal Cancer Risk
#345: Rebecca Leech, PhD – Impact of Meal Patterning on Diet Quality & Health
#344: Prof. Martin Caraher – Food Poverty & Food Aid Provision
#343: Understanding Causality in Nutrition Science
#342: Are Vegan Diets Superior for Health?
#340: Ethics of Veganism & Omnivorism (Part 4) – Diana Rodgers, RD & Robb Wolf
#339: Prof. Corinna Hawkes - Food Policy, Food Systems & Public Health
#338: Ethics of Veganism & Omnivorism (Part 3) - Alex O' Connor
#337: Ethics of Veganism & Omnivorism (Part 2) – Prof. Paul Thompson
#336: Ethics of Veganism & Omnivorism (Part 1) – Andrew Chignell, PhD
#335: Kyra Bobinet, MD – Systems, Dietary Behaviour Change & the Iterative Mindset
#334: Austin Baraki, MD – Potential Harms of Screening, Overdiagnosis and Overtreatment
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