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About This Episode:
In 1959 a landmark clinical trial, often referred to as the LA Veterans Study, began with the aim to investigate the effects of replacing dietary saturated fats with polyunsaturated fats, on the progression of atherosclerosis and cardiovascular outcomes.
This was an eight-year clinical trial in 846 domiciled male veterans in the US. The diets between the control and experimental groups differed by saturated fat and polyunsaturated fat (particularly linoleic acid) content, but were similar in calories and total dietary fat.
The findings of the study suggested that replacing saturated fat with polyunsaturated fat was beneficial for reducing heart disease risk. However, the study also reported an unexpected increase in non-cardiac mortality in the intervention group, which raised concerns.
In this episode, we discuss why the LA Veterans Study was such a seminal trial and what we can learn from it.
#333: Diet & Immunity
#332: Prof. Sam McConkey – COVID-19: Public Health Response, Clinical Presentation & Socioeconomics
#331: Prof. Roy Taylor – Diabetes Remission, Very-low Calorie Diets & the Twin Cycle Hypothesis
#330: Eric Trexler, PhD – Antioxidants, Oxidative Stress & Exercise Adaptations
#329: Diet & Inflammation
#328: Meeta Singh, MD – Sleep, Immunity & Mental Health
#327: David Dunne – Behavioural Science in Nutrition
#326: Krista Scott-Dixon, PhD – Adaptability & Autonomy in the Nutrition Coaching Process
#325: Kirk Parsley, MD - Stress, Sleep & Anxiety During a Pandemic
#324: Fatima Cody Stanford, MD – Obesity Treatment & Weight Bias
#323: COVID-19 & SARS-CoV-2 with Rizwan Sohail, MD
#322: Dominic Munnelly – Coaching People To Health: Philosophy, Empathy & Community
#321: Dave Feldman & Alan Flanagan – Debating LDL Causality & the “Lipid Triad”
#320: Hannah Ritchie, PhD – Environmental Impacts of our Diet: Climate, Carbon Footprint & Land Use
#319: Women in Science: Past Guests as Role Models in Nutrition
#318: Chris Melby, PhD – Impact of Energy Flux on Weight Loss Maintenance
#317: Understanding Diet & Heart Disease Risk
#316: Michael Grandner, PhD – Societal, Social & Psychological Influences on Sleep
#315: Samia Mora, MD – Lipids, Lipoproteins & Atherosclerosis
#314: Q&A – Hemochromatosis, Sodium, Bone Health, & More!
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