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About This Episode:
It has been clearly demonstrated that elevated LDL-cholesterol (LDL-C), or perhaps more specifically pro-atherogenic lipoproteins, is causal in atherosclerosis development in humans.
One crucial concept within this is that the risk relates not only to the magnitude of elevated LDL-C, but the duration of exposure. Thus, the role of LDL-C in driving atherosclerosis is referred to as a “cumulative, integrated exposure over the lifecourse”.
But, what exactly does this mean?
In this episode, Danny discusses the cumulative exposure model of LDL-C in atherosclerosis, the evidence supporting it, and the implications of this for the “debates” that get raised in relation to LDL-C (or apoB-containing lipoproteins) and heart disease.
Links:
#492: How Does Weight Cycling Impact Long-term Health?
#491: Do High Protein Intakes Cause Insulin Resistance?
#490: How Does Exercise Impact Beta-cell Function in Type 2 Diabetes? – Mark Lyngbæk, MD
What is a Causal Risk Factor? (AMA with Alan)
#489: Inequalities in Diabetes Outcomes for African & Caribbean Communities – Prof. Louise Goff
#488: Does Time of Day Impact Hunger, Appetite & Satiety?
#487: Weight Cutting in Combat Sports – Jordan Sullivan
#486: Blood Glucose Spikes: How High is Too High? – Mario Kratz, PhD & Nicola Guess, PhD
#485: Does Menopause Alter Appetite?
SNP18: What is a Healthy Low-Carb Diet?
#484: Is Metabolic Adaptation an Illusion? – Eric Trexler, PhD
#483: What are the Effects of Very High Fiber Intakes?
#482: Carbohydrate Quality & Health – Andrew Reynolds, PhD
Is Personalized Nutrition Superior to General Nutrition Advice? (SNP 17)
#481: Why Saturated Fat Really Does Impact Heart Disease Risk
#480: How Much Fiber Do We Need for Good Health? – Prof. Joanne Slavin
#479: Blood Glucose, CGM Use, Diabetes Remission & High-Protein for Diabetes – Nicola Guess, PhD, RD
#478: Exposures in Nutrition – Why They’re Crucial to Understand
SNP16: A Dairy Fat Paradox? – Saturated Fat, Food Matrices & Heart Disease
#477: Effect of Different Diets on Cholesterol, Lipoproteins and Discordance – Ian Davies, PhD
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