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About This Episode:
PREDIMED (Prevención con Dieta Mediterránea) is a landmark clinical trial conducted in Spain.
The study made a huge splash due to the rarity in nutrition of having large RCTs with hard endpoints. In addition, it had results of a large magnitude; showing a 30% reduction in cardiovascular events.
But the study did face criticisms and controversies over methodological issues, including randomization procedures at certain centers, ultimately leading to a retraction of the original paper and a re-analysis.
Participants in the PREDIMED trial were randomly assigned to one of three groups:
Despite the issues it still ends up being an incredibly useful source of data.
In this episode we discuss the findings from PREDIMED, some of the potential limitations, and where it sits among the wider Mediterranean Diet literature.
Note: This is a Premium-exclusive episode, so in order to listen to the full episode you’ll need to subscribe to Sigma Nutrition Premium.
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#491: Do High Protein Intakes Cause Insulin Resistance?
#490: How Does Exercise Impact Beta-cell Function in Type 2 Diabetes? – Mark Lyngbæk, MD
What is a Causal Risk Factor? (AMA with Alan)
#489: Inequalities in Diabetes Outcomes for African & Caribbean Communities – Prof. Louise Goff
#488: Does Time of Day Impact Hunger, Appetite & Satiety?
#487: Weight Cutting in Combat Sports – Jordan Sullivan
#486: Blood Glucose Spikes: How High is Too High? – Mario Kratz, PhD & Nicola Guess, PhD
#485: Does Menopause Alter Appetite?
SNP18: What is a Healthy Low-Carb Diet?
#484: Is Metabolic Adaptation an Illusion? – Eric Trexler, PhD
#483: What are the Effects of Very High Fiber Intakes?
#482: Carbohydrate Quality & Health – Andrew Reynolds, PhD
Is Personalized Nutrition Superior to General Nutrition Advice? (SNP 17)
#481: Why Saturated Fat Really Does Impact Heart Disease Risk
#480: How Much Fiber Do We Need for Good Health? – Prof. Joanne Slavin
#479: Blood Glucose, CGM Use, Diabetes Remission & High-Protein for Diabetes – Nicola Guess, PhD, RD
#478: Exposures in Nutrition – Why They’re Crucial to Understand
SNP16: A Dairy Fat Paradox? – Saturated Fat, Food Matrices & Heart Disease
#477: Effect of Different Diets on Cholesterol, Lipoproteins and Discordance – Ian Davies, PhD
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