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About This Episode:
PREDIMED (Prevención con Dieta Mediterránea) is a landmark clinical trial conducted in Spain.
The study made a huge splash due to the rarity in nutrition of having large RCTs with hard endpoints. In addition, it had results of a large magnitude; showing a 30% reduction in cardiovascular events.
But the study did face criticisms and controversies over methodological issues, including randomization procedures at certain centers, ultimately leading to a retraction of the original paper and a re-analysis.
Participants in the PREDIMED trial were randomly assigned to one of three groups:
Despite the issues it still ends up being an incredibly useful source of data.
In this episode we discuss the findings from PREDIMED, some of the potential limitations, and where it sits among the wider Mediterranean Diet literature.
Note: This is a Premium-exclusive episode, so in order to listen to the full episode you’ll need to subscribe to Sigma Nutrition Premium.
#507: Does a Higher Portfolio Diet Score Reduce Heart Disease? – Andrea Glenn, PhD
Listener Q&A: Homocysteine, MUFA, Healhty BMI, and more! (Preview)
#506 Sports Nutrition: Translating Research to Practice – Andreas Kasper, PhD
#505: Oslo Diet-Heart Study: Cholesterol-lowering Diets & Cardiovascular Events
#504: Vegetable Oil vs. Saturated Fat – Analysis of the LA Veterans Study
#503: Lyon Diet Heart Study – Canola Oil, “Mediterranean” Diets & Minimizing Bias
#502: Sydney Diet-Heart Study – Is Linoleic Acid Causing Heart Disease?
Addressing Some Criticisms of Nutritional Epidemiology (SNP 23)
#501: Sex-based Training Recommendations: Evidence-based or Hype? – David Nolan, PhD
#500 – The Big Unanswered Questions in Nutrition Science
#499: How Sensory Cues Impact Food Choice & Behavior – Prof. Ciarán Forde
#498: The PROPEL Trial & Weight Loss Interventions in Primary Care – John Apolzan, PhD
#497: Are Food Frequency Questionnaires Reliable?
SNP21: Sick Individuals and Sick Populations
#496: ATBC Cancer Prevention Study – Crucial Lessons
#495: Circadian Clocks in Muscle & Exercise as a Time Cue – Prof. Karyn Esser
#494: Multiple Risk Factor Intervention Trial
#493: The Keys Equation – How Dietary Fats Impact Blood Cholesterol
SNP20: The Cumulative Exposure Model of LDL-C & Heart Disease
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